Non-bonding 1,5-S···O interactions govern chemo- and enantioselectivity in isothiourea-catalyzed annulations of benzazoles† †Electronic supplementary information (ESI) available: 1H and 13C{1H} NMR spectra and HPLC traces of all novel compounds. Coordinates, thermal corrections, and energies of all computed structures. See DOI: 10.1039/c6sc00940a Click here for additional data file. Click here for additional data file.

Dynamic induction of enantiomeric excess from a prochiral azobenzene dimer under circularly polarized light† †Electronic supplementary information (ESI) available: Synthesis, 1H NMR spectra, 13C NMR spectra, UV absorption plots, HPLC traces, and CD spectra of the compounds; crystallographic information files. CCDC 1003754. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc01993h Click here for additional data file. Click here for additional data file.

6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis† †Electronic supplementary information (ESI) available: Experimental procedures; characterization data for novel compounds; 1H and 13C NMR spectra, HPLC traces,12 and X-ray crystallographic data files compounds 9 and 27 (CIF). CCDC 1510311 and 1510312. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6cc10178j Click here for additional data file. Click here for additional data file.

The catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea tetramisole. An acidic workup proved necessary to minimize product epimerization and maximize product er, providing cis-chromenones in excellent yield, and with excellent diast...

Copper-catalyzed direct alkylation of heteroarenes† †Electronic supplementary information (ESI) available: Experimental procedures, characterization and copies of 1H and 13C NMR spectra for all new compounds. See DOI: 10.1039/c6sc05622a Click here for additional data file.

Enantioselective synthesis of (–)-chloramphenicol via silver-catalysed asymmetric isocyanoacetate aldol reaction† †Electronic supplementary information (ESI) available: Experimental procedures, characterisation data, copies of 1H and 13C NMR spectra, and HPLC traces. See DOI: 10.1039/c5ob02141c Click here for additional data file.

Stereodivergent, Diels–Alder-initiated organocascades employing α,β-unsaturated acylammonium salts: scope, mechanism, and application† †Electronic supplementary information (ESI) available: Experimental procedures and characterization details for all new compounds including 1H and 13C NMR spectra, computational data, crystallographic data, chiral phase-HPLC traces. CCDC 972246. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04273b Click here for additional data file. Click here for additional data file.

Chiral a,b-unsaturated acylammonium salts are novel dienophiles enabling enantioselective Diels–Alderlactonization (DAL) organocascades leading to cisand trans-fused, bicyclic gand d-lactones from readily prepared dienes, commodity acid chlorides, and a chiral isothiourea organocatalyst under mild conditions. We describe extensions of stereodivergent DAL organocascades to other racemic dienes b...